On the Dynamics of Certain Models Describing the HIV Infection
Jorge Zubelli | Pastore, Dayse
Immunology; Mathematical modeling; Human immune response; HIV modeling
This article concerns some global stability aspects of a class of models introduced by Nowak and Bangham that describe in a fairly successful way the initial phases of the HIV dynamics in the human body as well as some generalizations that take into account mutations. We survey recent results implying that the biologically meaningful positive solutions to such models are all bounded and do not display periodic orbits. For the mutationless cases the dynamics is characterized in terms of certain dimensionless quantities, the so-called basic reproductive rate and the basic defense rate. As a consequence, we infer that the finite dimensional models under consideration cannot account, without further modifications, for the third phase of the HIV infection. We conclude by suggesting a modification that according to our numerical simulations may describe the collapse of the infected patient.